abstract：BACKGROUND:Atrial fibrillation (AF) is the most common supraventricular arrhythmia in clinical practice. Chronic atrial fibrillation (CAF) is associated with ionic remodeling. However, little is known about the activity of ATP-sensitive potassium current (IK, ATP) during CAF. So we studied the changes of IK, ATP densit...

journal_title：Chinese medical journal

authors： Wu G,Huang CX,Tang YH,Jiang H,Wan J,Chen H,Xie Q,Huang ZR

更新日期：2005-07-20 00:00:00

abstract：BACKGROUND:Previous studies have showed that photooxidative stress can lead to down-modulation of nuclear factor-kappa B (NF-kappaB) activity causing apoptosis of cultured photoreceptor cells. This study aimed at investigating whether NF-kappaB was involved in photoreceptor cells apoptosis induced by N-methyl-N-nitroso...

journal_title：Chinese medical journal

authors： Yang JN,Luo L,Lin SC,Chen JM,Li D,Hu SX

更新日期：2005-07-05 00:00:00

abstract：BACKGROUND:Up to now there have been no satisfactory drugs to treat psychiatric disorders, and now bioactive compound from entomagenous fungi (BCEF0083) is a new type of bioactive compound from entomopathogenic fungi. Our previous investigations have shown that BCEF has an inhibition effect on monoamine oxidase. So, BC...

journal_title：Chinese medical journal

authors： Zhou LL,Ming L,Ma CG,Cheng Y,Jiang Q

更新日期：2005-06-05 00:00:00

abstract：BACKGROUND:Tumor involving the septum pellucidum is uncommon. Surgery as the main therapeutic procedure for this lesion is a challenge to neurosurgeons. We analyzed the clinical characteristics and pathological features of septum pellucidum tumor in 41 patients and compared the curative effects of frontal transcortical...

journal_title：Chinese medical journal

authors： Wang L,Zhang MZ,Zhang W,Zhao SF,Zhao JZ,Jia JX

更新日期：2005-05-20 00:00:00

abstract：BACKGROUND:The rapid transmission and high mortality rate made severe acute respiratory syndrome (SARS) a global threat for which no efficacious therapy is available now. Without sufficient knowledge about the SARS coronavirus (SARS-CoV), it is impossible to define the candidate for the anti-SARS targets. The putative ...

journal_title：Chinese medical journal

authors： Lu JH,Zhang DM,Wang GL,Guo ZM,Zhang CH,Tan BY,Ouyang LP,Lin L,Liu YM,Chen WQ,Ling WH,Yu XB,Zhong NS

更新日期：2005-05-05 00:00:00

abstract：BACKGROUND:Selection of patients with hepatocellular carcinoma (HCC) for orthotopic liver transplantation (OLT) remains controversial. Since there is a trend to expand the transplant criteria for HCC patients, we reviewed the data of patients with HCC who had received OLT at our institute to determine their survival an...

journal_title：Chinese medical journal

authors： Zhou J,Fan J,Wu ZQ,Qiu SJ,Huang XW,Yu Y,Wang Z,Sun J,Xiao YS,He YF,Yang GH,Song K,Yuan Z,Wang YQ,Tang ZY

更新日期：2005-04-20 00:00:00

abstract：BACKGROUND:Homoharringtonine (HHT) is a cephalotaxine ester derived from an evergreen tree found wildely throughout southern China, which has antileukemic activities against a variety of acute myeloid leukemic cells. For the sake of illustrating the mechanisms of HHT in the treatment of leukemia, we assessed the effect...

journal_title：Chinese medical journal

authors： Mai WY,Lin MF

更新日期：2005-03-20 00:00:00

abstract：BACKGROUND:The heavy incidence and mortality of hemorrhagic fever with renal syndrome, as well as no specific drugs in curing the disease, clearly indicate the need for development of the more effective hantavirus vaccine. Refining the DNA vaccination strategy to elicit more clinically efficacious immune responses is n...

journal_title：Chinese medical journal

authors： Zheng LY,Mou L,Lin S,Lu RM,Luo EJ

更新日期：2005-02-20 00:00:00

abstract：BACKGROUND:Tuberous sclerosis (TS) is an autosomal dominant disorder with a significant range of clinical expressions. The involvement of vital organs, such as the brain, kidney, heart and lung is the main cause of death in patients with TS. The aim of this study is to summarize the characteristic cutaneous features an...

journal_title：Chinese medical journal

authors： Sun XF,Yan CL,Fang L,Shen FM,Liao KH

更新日期：2005-02-05 00:00:00

abstract：BACKGROUND:Acinetobacter baumannii is one of the main gram-negative bacilli in clinical practice. Nosocomial infections caused by multi-drug resistance Acinetobacter baumannii is very difficult to treat. This study was designed to investigate the antimicrobial resistance characteristics and four resistant gene expressi...

journal_title：Chinese medical journal

authors： Shi WF,Jiang JP,Mi ZH

更新日期：2005-01-20 00:00:00

abstract：BACKGROUND:Hypoxic pulmonary hypertension (HPH) is initiated by inhibition of O2-sensitive, voltage-gated (Kv) channels in pulmonary arterial smooth muscle cells (PASMCs). The mechanism of hypoxic pulmonary hypertension has not yet been fully elucidated. The mitochondrial ATP-sensitive K+ channel (MitoKATP) is extremel...

journal_title：Chinese medical journal

authors： Wang T,Zhang ZX,Xu YJ

更新日期：2005-01-05 00:00:00

abstract：BACKGROUND:Although there were several clinical and experimental studies discussing the pathogenesis of dural arteriovenous fistula (DAVF), the pathological process leading to intracranial DAVF so far remains unknown. In this study, we investigated the expression of vascular growth factors in order to elucidate the pos...

journal_title：Chinese medical journal

authors： Tirakotai W,Bian LG,Bertalanffy H,Siegfried B,Sure U

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Cardiovascular diseases, especially coronary artery disease (CAD), are major causes of death in industrialized countries. Elevated concentrations of plasma homocysteine (Hcy) have been associated with an increased risk of CAD. Increased plasma levels of chemokine, characterized by their ability to induce mig...

journal_title：Chinese medical journal

authors： Wang G,Mao JM,Wang X,Zhang FC

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Although there are several drugs and drug combinations for the treatment of Pneumocystis carinii (P. carinii) pneumonia, all drugs have the toxicity as well as low efficacy. Iron chelators have been proposed as a source of new drugs for combating these infections. We hypothesized that iron chelators would su...

journal_title：Chinese medical journal

authors： Ye B,Zheng YQ,Wu WH,Zhang J

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that circulating DNA may be a potential tumor marker for lung cancer, but most of these studies are conducted between healthy controls and lung cancer patients, with few or no benign lung disease patients included. The objective of this study was to evaluate the performance of plasma D...

journal_title：Chinese medical journal

authors： Xie GS,Hou AR,Li LY,Gao YN,Cheng SJ

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Hypoxia-inducible factor 1 (HIF-1), a transcription factor, is overexpressed in common human cancers and their metastases. This study aimed at determining the expression levels of HIF-1alpha and vascular endothelial growth factor (VEGF) in SW480 cells and in colorectal adenocarcinoma tissue and ascertaining ...

journal_title：Chinese medical journal

authors： Jiang CQ,Fan LF,Liu ZS,Qian Q,Xia D,Diao LM,He YM,Ai ZL

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Cubital tunnel syndrome is a well-recognized clinical condition and is the second most common peripheral compression neuropathy. This study was designed to investigate the causes of cubital tunnel syndrome by surgical means and to assess the clinical value of the neurophysiological diagnosis of cubital tunne...

journal_title：Chinese medical journal

authors： Jia ZR,Shi X,Sun XR

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:This study was designed to obtain a recombinant retroviral vector containing the human hepatocellular carcinoma-related gene ANGPTL4 (angiopoietin-like 4) cDNA and to evaluate the anti-tumor effect of recombinant retroviral vector-mediated human ANGPTL4 gene transfection. METHODS:ANGPTL4 cDNA was cloned in ...

journal_title：Chinese medical journal

authors： Li KQ,Li WL,Peng SY,Shi XY,Tang HL,Liu YB

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Corneal dystrophy is a group of inherited blinding diseases of the cornea. This study was to identify the mutations of the keratoepithelin (KE) gene for proper diagnosis of corneal dystrophy. METHODS:Three families with corneal dystrophy were analysed. Thirteen individuals at risk for corneal dystrophy in f...

journal_title：Chinese medical journal

authors： Li Y,Sun XG,Ren HY,Dong B,Wang ZQ,Sun XY

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Transforming growth factor-beta1 (TGF-beta1) exerts strong fibrogenic potential in culture-activated HSCs. Smad4 is a key intracellular mediator for the transforming growth factor-beta (TGF-beta) superfamily of growth factors. The aim of this study was to assess the effects of the antisense Smad4 gene on Ito...

journal_title：Chinese medical journal

authors： Xu XB,Leng XS,He ZP,Liang ZQ,Lin K,Wei YH,Yu X,Peng JR

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Extracellular matrix (ECM) orchestrates cell behaviour including growth, death, apoptosis, adhesion, migration, and invasion by activating several signalling pathways. Certain components of ECM, such as integrins, may act as receptors or co-receptors of enterovirus. ECM-activated gene expressions in myocardi...

journal_title：Chinese medical journal

authors： Zhang ZC,Li SJ,Yang YZ,Chen RZ,Ge JB,Chen HZ

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Connective tissue growth factor (CTGF) contributes greatly to renal tubulointerstitial fibrosis, which is the final event leading to end-stage renal failure. This study was designed to investigate the effects of CTGF antisense oligodeoxynucleotides (ODNs) on the expressions of plasminogen activator inhibitor...

journal_title：Chinese medical journal

authors： Zhang C,Meng XF,Zhu ZH,Yang X,Deng AG

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:In obscure gastrointestinal (GI) bleeding, it is often difficult to detect the bleeding sites located in the small bowel with conventional radiological, scintigraphic or angiographic techniques. Push enteroscopy and capsule endoscopy are currently considered to be the most effective diagnostic procedures. Th...

journal_title：Chinese medical journal

authors： Ge ZZ,Hu YB,Xiao SD

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Off-pump coronary artery bypass grafting is fast-becoming a procedure of choice for elective revascularization in high-risk patients with multi-vessel coronary artery disease. However, the role of off-pump coronary artery bypass grafting for patients with acute coronary syndromes requiring emergency revascul...

journal_title：Chinese medical journal

authors： Raja SG,Haider Z,Zaman H

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:In China the ginseng root began to be used in medicine over 2000 years ago. Ginsenosides are the most important component isolated from ginseng. The authors investigated the effect of ginsenoside Rg1 on the spectrum of gene expression in the endothelial cells stimulated by TNF-alpha and further explored the ...

journal_title：Chinese medical journal

authors： Lü JP,Ma ZC,Yang J,Huang J,Wang SR,Wang SQ

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:We assessed whether the CaNa2 EDTA could improve the accumulation of protoporphyrin IX (PpIX) and photosensitisation in HEp-2 cells as well as the depth of treatment of skin cancers on the topical 5-Aminolaevulinic acid (5-ALA) PDT. METHODS:HEp-2 cells were incubated with 5-ALA (0-1 mmol/L) and CaNa2EDTA (0...

journal_title：Chinese medical journal

authors： Liu HF,Xu SZ,Zhang CR

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD). However, only 10% - 20% of chronic heavy cigarette smokers develop symptomatic disease. COPD is most likely the result of complex interactions between environmental and genetic factors. Genetic susceptibility to COPD...

journal_title：Chinese medical journal

authors： Xiao D,Wang C,Du MJ,Pang BS,Zhang HY,Xiao B,Liu JZ,Weng XZ,Su L,Christiani DC

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Caspases are important in the signaling pathway of cellular apoptosis. Caspase-3 protein expression has been shown to increase and parallel to neuronal apoptosis in retinal ischemia injury. This study was to determine whether caspase-1 is involved in neuronal cell death or in retinal ischemia and reperfusion...

journal_title：Chinese medical journal

authors： Zheng GY,Zhang C,Li ZG

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:This study was designed to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) level and acute myocardial infarction (AMI) and coronary heart disease (CHD) death and to explore the protective effect of HDL against CHD in the elderly Chinese. METHODS:Started from 1986, 1211 retiree...

journal_title：Chinese medical journal

authors： Li JZ,Chen ML,Wang S,Dong J,Zeng P,Hou LW

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Ischemic disease is one of the leading causes of death in the world. In order to further study gene therapy for ischemic disease, we constructed a recombinant plasmid for co-expression of human angiopoietin-1 and vascular endothelial growth factor 165(VEGF165) gene in adeno-associated virus (AAV) gene delive...

journal_title：Chinese medical journal

authors： Chen DJ,Tan Z,Xie YL,Liu F

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Studies on selected patients undergoing off-pump versus on-pump coronary artery bypass surgery have produced inconsistent results, especially in patients with multiple coronary artery disease. This study compared the clinical results of on-pump and off-pump coronary bypass surgery in patients with triple-ves...

journal_title：Chinese medical journal

authors： Chen X,Xu M,Shi HW,Mu XW,Chen ZQ,Qiu ZB

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The activation of extracellular signal-regulated kinase1/2 (ERK1/2) has been shown to be important signaling pathway in the ischemic preconditioning (IPC) response. Recently, some studies suggest a key role for the mitochondrial ATP-sensitive potassium channel (mKATP) as both a trigger and an end effector of...

journal_title：Chinese medical journal

authors： Gong KZ,Zhang ZG,Li AH,Huang YF,Bu P,Dong F,Liu J

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of misoprostol in term labour induction. DATA SOURCES:Data from published English and Chinese literatures about misoprostol in term labour induction were identified from Medline and CBMdisk (using the search terms "misoprostol" and "labour induction") before 2001; hand sea...

journal_title：Chinese medical journal

authors： Li XM,Wan J,Xu CF,Zhang Y,Fang L,Shi ZJ,Li K

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:To compare the efficacy and safety of hormone replacement therapy (HRT) combined with fluoxetine, with HRT alone, in post-menopausal women suffering from depression. METHODS:A randomized, open-label, parallel trial was applied. HRT was administered to all patients for 2 cycles, with 14 days of estrogen ther...

journal_title：Chinese medical journal

authors： Liu P,He FF,Bai WP,Yu Q,Shi W,Wu YY,He DJ,Xiao JH,Zheng Y,Liao QP

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Ilexonin A (IA), purified from the Chinese herbal medicine Maodongqing (Ilex pubescens Hook, et Arn) has been commonly used in south China to treat thrombotic disorders. In this study, we aimed to study the inhibiting effects and mechanism of IA on von Willebrand factor (vWF)-dependent high shear-induced pla...

journal_title：Chinese medical journal

authors： Li M,Wu WK,Liu L,Liao FL,Shinohara Y,Handa S,Goto S

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Human urotensin II (UII) is the most potent mammalian vasoconstrictor identified so far. Our previous study showed that UII is a potent mitogen of airway smooth muscle cells (ASMC) inducing ASMC proliferation in a dose-dependent manner. The signal transduction pathway of UII mitogenic effect remains to be cl...

journal_title：Chinese medical journal

authors： Chen YH,Zhao MW,Yao WZ,Pang YZ,Tang CS

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:The development of new adjuvants for human use has been the focus of attention. This study's aim is to explore the possibility of using nanoparticle Ca nanoparticles (CA) as a vaccine adjuvant of anti-idiotypic antibody NP30 against schistosomiasis and its protective mechanisms. METHODS:Nanoparticle CA-NP30...

journal_title：Chinese medical journal

authors： Feng ZQ,Zhong SG,Li YH,Li YQ,Qiu ZN,Wang ZM,Li J,Dong L,Guan XH

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:To determine the distribution of aortic arch and intra/extracranial cerebral arterial atherosclerosis in Chinese patients who had suffered acute ischemic strokes. METHODS:Eighty-nine patients with acute ischemic strokes were included in this study. Transesophageal echocardiography (TEE) was used to evaluate ...

journal_title：Chinese medical journal

authors： Guo Y,Jiang X,Chen S,Zhang S,Zhao H,Wu Y

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To investigate an method for hepatic differentiation from embryonic stem cells (ES cells) in vitro and the resulting differentiation ratio, in order to develop a procedure for producing a new type of hepatocyte for hepatocyte replacement therapy in the treatment of liver failure. METHODS:ES cells from Balb/C...

journal_title：Chinese medical journal

authors： Hu A,Cai J,Zheng Q,He X,Pan Y,Li L

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:To report the surgical techniques and results of an 8-year follow-up study of 42 patients with a modified orthotopic ileal neobladder restoring normal anatomical relationship. METHODS:Total cystoprostatectomy was performed extraperitoneally. A 45 - 50 cm segment of the ileal loop was isolated, detubularized,...

journal_title：Chinese medical journal

authors： Huang J,Xu K,Yao Y,Guo Z,Lin T,Jiang C

更新日期：2003-12-01 00:00:00